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Endobiogeny: An Introduction For Physicians

Endobiogeny: An Introduction for Physicians
Dan Kenner PhD, Patrice Pauly PhD, Kamyar M. Hedayat MD, Jean Claude Lapraz MD

Endobiogeny is a system-based approach to clinical practice that reflects fundamental principles of physiology and pathophysiology based on an integrated approach to the neuroendocrine management of the organism. Developed over thirty years ago by two French physicians, Drs. C. Duraffourd and J.C. Lapraz, Endobiogeny is an integrative study of the functional mechanisms of regulation of the organism in its basic structure during homeostasis as well as its functional response to internal and external stressors.

As a system-based approach, Endobiogeny simultaneously considers the whole system, its individual units of function, core metabolism, cell, tissue and organ activity in and of themselves as well as in relationship to each other, enabling the physician to evaluate qualitative and quantitative state of each individual patient.

Patients diagnosed with identical diseases can respond very differently to the same treatment because the factors influencing the severity of disease reflect a terrain or internal milieu unique to that individual. Thus, each patient must be assessed and treated based on the set of factors most responsible for the onset and perpetuation of their disorder.

The Endocrine System in Endobiogeny
The Endobiogenic approach uses the endocrine system as a functional model of systems management. The endocrine system is observable at the clinical level, apparent to the trained eye as various recognizable aspects of morphology, personality, and various measurable physiological parameters as well as symptoms. For example, lower abdominal fat deposition is a reflection of estrogen’s role in anabolism. Adrenaline (a neurohormone) induces increased physical activity, increase heart rate and pulse amplitude.

In the face of a permanent state of flux, the body requires a dynamic system capable of simultaneously checking, balancing, managing the organism while managing itself. The endocrine system is the only system that possess these qualities, thus it is the primary object of study in Endobiogeny. Hormones serve as an executor of all metabolic demands of the body as well as carriers of information. They also act as a liaison between external and internal milieus: environment vs. self, extracellular vs. intracellular, extranuclear vs. intranuclear, between the neurologic and immune spheres of activity. It fulfills the need for a systems biology approach to medicine with clinical applications that addresses the global matrix of regulation.

It is no surprise then that Endobiogeny is structured around the activity of four neuroendocrine axes of regulation: hypothalamus-pituitary-adrenal, hypothalamus-pituitary-gonadal, hypothalamus-pituitary-thyroid, and hypothalamus-pituitary-somatotropic (pancreas), tied together through multiple relationships (vertical, horizontal and radial).

The influence of hormones related to these axes extends to their intracellular action. The effects of hormones on cellular functions access the signaling pathways from the cell wall through the cytoplasm up to the nuclear membrane. They influence energy production, trigger protein synthesis, lysis, energy storage and release, and waste elimination. Hormonal signaling is a constant factor throughout the hierarchy of the various levels of biological activity from the intracellular level up to morphology and behavior.

Endobiogenic Biological Evaluation
Patient biological evaluation in Endobiogeny requires both a qualitative assessment of a patient’s individual condition carried out by means of a detailed history and physical examination, as well as a quantitative assessment of physiological disorders that are the root causes of pathology.
Conventional blood testing methodology is insufficient for understanding and modeling the full complexity of signaling pathways and the inter-relatedness of the neurologic, endocrine and immunologic systems. Because functionality is dynamic, a dynamic, integrated and evolutionary methodology must be used instead of static lab values.

To resolve this issue, a biological modeling system was developed by Dr Duraffourd, based on a number of specific indices defined by mathematical relations between commonly used blood analysis data. This modeling system quantifies functional abilities of the organism, before and after the effects of adaptation to stressors. The algorithms that permit the calculation of these indices are based on the physiological relations that exist between the direct or indirect products of hormonal activity: cells, hormones or enzymes (e.g. eosinophils, TSH, LDH). Thus, a simple panel of static serum chemistries, when entered into the modeling algorithm yields over 100 indices.

These relations allow one to visualize the functioning of the organism at every level: maintenance of homeostasis, adaptation, recovery after aggression, immunity, etc. Each function is quantified by an index, specified by a level of activity. The index expresses the actual activity of that function, both in and of itself and in relation to the metabolic and tissue needs of the organism. The whole set of indices gives an evolutionary assessment of an individual body’s functionality, system by system, organ by organ.

In addition, the system program helps to indicate and prioritize therapeutic interventions with a higher degree of specificity than could be determined by empirical observation, examination or classical blood chemistries alone.

Because the indices are reproducible with each subsequent blood sampling, the system gives the physician a way to track the evolution and devolution of pathology as well as the efficiency of treatment.

After a period of development and refinement, this modeling system has now been in clinical application for over twenty years in thousands of patients.

Therapeutic strategy
The Endobiogenic therapeutic strategy is the result of a thorough clinical examination supported by the physiological data given by the expert system.

It addresses the overall imbalances of the organism through using drainage techniques of organs and neuroendocrine corrective actions, whatever is the type of pathology: organic, immune, degenerative, infectious, etc. in order to restore a balanced metabolic functioning of the body.

It uses, according to needs: medicinal plants, nutritional supplementation, dietary and lifestyle regulation, pharmaceutical and surgical interventions when required.

If you would like to learn more about how Endobiogeny can be helpful to your patients please feel free to contact us.